The Team Tony WHITEHOUSE Chief Investigator Consultant Critical Care, Queen Elizabeth Hospital Birmingham Julian BION Co-Applicant Professor of Intensive Care, University of Birmingham Paul DARK Member, Data Monitoring Committee Professor of Intensive Care, University of Manchester Simon GATES Co-applicant and Member, Trial Management Group Professor of Clinical Trials, Institute of Cancer and Genomic Sciences, University of Birmingham Belinder GHUMAN Warwick Clinical Trials Unit Data Entry clerk Tony GORDON Co-Applicant and Member of Trial Management Group Professor of Intensive Care, Imperial College London David HARRISON Chair, Data Monitoring Committee Honorary Professor, Head Statistician at ICNARC Charles HINDS Trial Steering Committee Professor of Intensive Care - Queen Mary, University of London Claire HULME Trial Steering Committee Professor of Health Economics, University of Leeds Ranjit LALL Warwick Principal Investigator and Member, Trial Management Group Principal Research Fellow, Warwick CTU Janet LORD Co-Applicant Director of the Institute of Inflammation and Ageing, University of Birmingham Danny McAULEY Co-Applicant Professor Queens University of Belfast Dipesh MISTRY Senior Research Fellow and Member, Trial Management Group Warwick CTU Rupert PEARSE Member, Data Monitoring Committee NIHR Professor of Intensive Care Medicine, Queen Mary University of London Gavin PERKINS Co-Applicant Professor in Critical Care Medicine, Director Warwick CTU Scott REGAN Senior Project Manager Warwick CTU Mervyn SINGER Co-Applicant Professor Intensive Care, University College London Emma SKILTON Trial Manager Clinical Trial Coordinator, Warwick CTU Tim WALSH Chair, Trial Steering Committee Professor of Intensive Care, University of Edinburgh Duncan YOUNG Co-Applicant Professor of Intensive Care, University of Oxford